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Clinical trials for Extracellular Matrix

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43874   clinical trials with a EudraCT protocol, of which   7294   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    17 result(s) found for: Extracellular Matrix. Displaying page 1 of 1.
    EudraCT Number: 2015-000413-48 Sponsor Protocol Number: 8.1(IRE),2017.03.24 Start Date*: 2015-07-01
    Sponsor Name:ACS Biomarker
    Full Title: Bioprofiling response to mineralocorticoid receptor antagonists for the prevention of heart failure. A proof of concept clinical trial within the EU FP 7 “HOMAGE” programme « Heart OMics in AGing
    Medical condition: Elderly patients with Clinical and Biological risk factors for developing heart failure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Prematurely Ended) NL (Prematurely Ended) GB (Prematurely Ended) DE (Completed) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-003148-38 Sponsor Protocol Number: 1199.227 Start Date*: 2016-06-13
    Sponsor Name:Boehringer Ingelheim España, S.A.
    Full Title: A 12-week, double blind, randomised, placebo controlled, parallel group trial followed by a single active arm phase of 40 weeks evaluating the effect of oral nintedanib 150 mg twice daily on change...
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    18.1 10038738 - Respiratory, thoracic and mediastinal disorders 10021240 Idiopathic pulmonary fibrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) CZ (Completed) FI (Completed) HU (Completed) GB (Completed) BE (Completed) FR (Completed) DE (Completed) PL (Completed)
    Trial results: View results
    EudraCT Number: 2007-004616-31 Sponsor Protocol Number: FR1 Start Date*: 2008-04-11
    Sponsor Name:Universitair Medisch Cemtrum Utrecht
    Full Title: Prevention of neutrophil induced extracellular matrix damage following skin exposure to solar simulating radiation (SSR)
    Medical condition: sunburn (erythema solaris), photoaging (elastosis solaris)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000705 Acute dermatitis due to solar radiation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000214-37 Sponsor Protocol Number: Wallstrength_01 Start Date*: 2007-08-07
    Sponsor Name:UMC St Radboud
    Full Title: Biological and biochemical markers of aneurysm wall degradation; towards non-invasive wall strength analysis.
    Medical condition: Abdominal aortic aneurysms. Biomarkers related to diminished aneurysm wall strength.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000051 Abdominal aneurysm LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-002046-20 Sponsor Protocol Number: FIBHGM-ECNC001-2019 Start Date*: 2020-07-22
    Sponsor Name:Fundación para la Innovación en Biomedicina-FIBMED
    Full Title: Effects of SGLT2 inhibition on the mechanisms of cardiac damage in the diabetic patient with HFpEF.-CARDIA-STIFF.
    Medical condition: Patients with Diabetes mellitus type 2 and Heart Failure with preserved Ejection Fraction.
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-002749-40 Sponsor Protocol Number: DREAM-GR-2018-12367168 Start Date*: 2019-12-02
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Intervertebral Disc REgeneration mediated by Autologous Mesenchymal stem/stromal cells intradiscal injection: a phase IIB randomized clinical trial.
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-000995-41 Sponsor Protocol Number: FBX104114 Start Date*: 2007-02-20
    Sponsor Name:GlaxoSmithKline R&D
    Full Title: A double-blind, randomized, placebo-controlled multi-centre, phase II parallel dose-ranging study to assess the antifibrotic activity of GI262570 in chronic hepatitis C subjects with hepatic fibros...
    Medical condition: Chronic hepatitis C subjects with hepatic fibrosis who have failed prior antiviral therapy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2020-000982-18 Sponsor Protocol Number: NOR-SOLIDARITY Start Date*: 2020-03-26
    Sponsor Name:Oslo University Hospital
    Full Title: The NOR Solidarity multicenter trial on the efficacy of different anti-viral drugs in SARS-CoV-2 infected patients (COVID-19).
    Medical condition: SARS-COV-2 infection
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004855 10037373 Pulmonary disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Ongoing) SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-002036-90 Sponsor Protocol Number: Uni-Koeln-3815 Start Date*: 2019-12-02
    Sponsor Name:University of Cologne
    Full Title: A randomized, placebo-controlled phase IIa clinical trial to evaluate the efficacy and safety of subcutaneous Dupilumab in localized scleroderma
    Medical condition: Localized scleroderma
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10009206 Circumscribed scleroderma LLT
    21.0 100000004859 10018124 Generalized scleroderma LLT
    20.0 100000004859 10027979 Morphea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003408-65 Sponsor Protocol Number: Start Date*: 2016-08-26
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)
    Medical condition: Heavy menstrual bleeding
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004864 10046784 Uterine fibroids LLT
    18.0 10038604 - Reproductive system and breast disorders 10027313 Menorrhagia PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2010-020763-20 Sponsor Protocol Number: 10072DMcA-CS Start Date*: 2010-10-04
    Sponsor Name:National University of Ireland, Galway
    Full Title: Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP 2)
    Medical condition: Acute lung injury
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2015-003131-35 Sponsor Protocol Number: AA-HPP-208 Start Date*: 2016-04-19
    Sponsor Name:Alexion Pharma GmbH
    Full Title: A Phase 2a Randomized, Multi-center, Open-Label, Pharmacokinetic, and Dose Response Study of Asfotase Alfa in Adult Patients with Pediatric-Onset Hypophosphatasia
    Medical condition: Hypophosphatasia is a rare inborn error of bone metabolism caused by inactivating mutations in the gene encoding the Tissue-nonspecific alkaline phosphatase isoenzyme. With deficiency of Tissue-no...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10049933 Hypophosphatasia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2019-004476-19 Sponsor Protocol Number: ACTIVE-BRIC2018–ID03 Start Date*: 2020-04-28
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Autologous mesenchymal stem/stromal Cells for the Treatment of workers affected by chronic low back pain due to multilevel InterVErtebral disc degeneration: a phase IIB randomized clinical trial - ...
    Medical condition: Symptomatic chronic low back pain due to a degenerative disease of the intervertebral disc
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10070241 Degenerative disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-003743-10 Sponsor Protocol Number: 2016-779 Start Date*: 2017-02-06
    Sponsor Name:Herlev og Gentofte Hospital
    Full Title: Effects of SGLT-2 Inhibitor on Myocardial Perfusion, Function and Metabolism in Type 2 DM Patients at high cardiovascular risk: The SIMPle Randomized Clinical Trial
    Medical condition: Type 2 diabetes and cardiovascular risk
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2019-004641-33 Sponsor Protocol Number: DIA2020-01 Start Date*: 2021-02-16
    Sponsor Name:Diakonhjemmet Hospital
    Full Title: The Methotrexate in ERosive INflammatory Osteoarthritis (MERINO) trial
    Medical condition: Norwegian adult males and females with symptomatic erosive inflammatory hand osteoarthritis.
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10016686 Finger osteoarthritis LLT
    21.1 100000004859 10019115 Hand osteoarthritis LLT
    21.0 100000004859 10064565 Erosive osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2010-019850-42 Sponsor Protocol Number: ENB-010-10 Start Date*: 2011-03-04
    Sponsor Name:Alexion Pharma GmbH
    Full Title: An Open-Label, Multicenter, Multinational Study of the Safety, Efficacy and Pharmacokinetics of Asfotase alfa (human recombinant tissue nonspecific alkaline phosphatase fusion protein) in Infants a...
    Medical condition: Hypophosphatasia is a rare inborn error of bone metabolism caused by inactivating mutations in the gene encoding the Tissue-nonspecific alkaline phosphatase isoenzyme. With deficiency of Tissue-...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10010331 - Congenital, familial and genetic disorders 10049933 Hypophosphatasia PT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed) IT (Completed) ES (Completed) FR (Ongoing)
    Trial results: View results
    EudraCT Number: 2007-005306-49 Sponsor Protocol Number: MK-0683-092 Start Date*: 2008-09-03
    Sponsor Name:Department of Haematology, Herlev Hospital, University of Copenhagen
    Full Title: A Phase II Study of Vorinostat in Patients with Polycythaemia Vera and Essential Thrombocythaemia
    Medical condition: patients with polycythaemia vera or essential thrombocythaemia or myelofibrosis
    Disease: Version SOC Term Classification Code Term Level
    9.1 10036057 Polycythaemia vera LLT
    9.1 10015493 Essential thrombocythaemia LLT
    12.1 10028537 Myelofibrosis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed) SE (Completed) NL (Completed) GB (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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